Effect of mid-follicular luteinizing hormone levels on ovarian response and pregnancy outcome in patients undergoing in vitro fertilization in short-term protocol

(Fertil Steril, 2005，Apr，83(4):1043-6.)

 Su-ying Liu, M.D., Ph.D.  Jin-lan Han, M.D. Xian-dong Peng, M.D. Xi Dong, M.D. Jun Xu, M.D.  Jing-ming Yan, M.D.

Shanghai Jiai Genetics & IVF Institute, Obstetrics & Gynecology Hospital, Fudan University, Shanghai, People’s Republic of China

(FAX:33180478  ;E-mail:liusuying2000@yahoo.com)

Objective: To evaluate the effects of mid-follicular LH levels on ovarian response and pregnancy outcome in patients undergoing in vitro fertilization in short-term protocol.Methods: 308 women undergoing IVF/ICSI treatment cycles with GnRH agonist administration in short-term protocol were studied. Results: Compared with patients of LH on day 8 <5IU/l, consumption of exogenous FSH and duration of gonadotrophin stimulation decreased significantly in those with LH on day 8 ≥5IU/l. The number of ≥15mm follicles, estradiol on HCG day were significantly increased, implantation and clinical pregnancy rates were decreased significantly. Conclusion(s): Circulating levels of LH on day 8 had a significant impact on ovarian response and pregnancy outcome, high LH levels in mid-follicular phase were associated with reduced implantation and clinical pregnancy rates.

Key words:  GnRH agonist,  in vitro fertilization,  luteinizing hormone,  ovarian response